Inis Biotech LLC

Consejo Nacional De Investigaciones Cientificas Y Tecnicas (conicet)

Onsejo Nacional De Investigation Cientiticay Tecnica

Fundocion Articula

Fundacion Articular

Andrea Nancy Chisari

Benito Jorge Velasco Zamora

Ricardo Alfredo Dewey

Tania Melina Rodríguez

Alejandra Carrea

Marcelo Javier Perone

Marcela Soledad Bertolio

Anabela Belen La Colla

Pamela Daiana Vazquez

Ana Romo

Matias Adan Preisegger

Tania Melina Rodriguez

An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2. A fusion peptide is provided comprising an isoform of the TGF beta II receptor fused to a ligand, wherein a vector comprising the fusion peptide is used to treat cancer and/or hepatic fibrosis. An antibody binding the soluble isoform of the TGF beta II receptor is provided. The antibody binds the amino acid sequence shown in SEQ ID No. 12 and is used in in vitro methods.

TGF-receptor II isoform, fusion peptide, methods of treatment and methods in vitro

An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain; wherein the isoform is a TGF&#x3b2;-1 agonist. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2.

Isoform of the TGF-beta receptor II

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Buenos Aires, Argentina

Andrea Nancy Chisari