Medimmune Limited

Humabs Biomed Sa

Andrea Minola

Davide Corti

Bret Sellman

Christine Tkaczyk

Melissa Marie Damschroder

Qun Du

Martin Borrok, Iii

The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to aclumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating ainfection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds toalpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

Antibody directed againstclumping factor A (ClfA)

The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventinginfections.

Antibodies directed againstleukotoxins

Antibody directed againstclumping factor a (ClfA)

Growing community of inventors

Bellinzona, Switzerland

Andrea Minola