Zambon Group

Cerbios-Pharma Sa

Zambon S.p.a.

Andrea Mereu

Franco Pellacini

Mauro Napoletano

Ermanno Moriggi

Fernando Ornaghi

Gabriele Morazzoni

Roberto Longoni

Luciano Pacchetti

Carlo Riva

Moreno Morosoli

Alessandro Vadala′

Mauro Perseghini

Maurizio Massara

Alessandro Spreafico

Alessandro (deceased) Spreafico

Complexes between an alkaline earth metal salt of (6RS)&#x2014; or (6S)&#x2014;N-methyl-(5,6,7,8)-tetrahydrofolic acid and a polyol were prepared by lyophilization or spray-drying. These products were found to be stable compared with the active ingredient alone or the mixture of the same components prepared by means of other methodologies.

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A continuous process for the alkylation of tertiary amines and, in particular, to a continuous process for the quaternization of cyclic tertiary amines useful for the preparation of cyclic quaternary ammonium salts with high purity is described.

Continuous process for the alkylation of cyclic tertiary amines

Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them as active ingredient.

Macrolide compounds endowed with antiinflammatory activity

Macrolide compounds of formula (I) wherein X, R, R, R, Rand R, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and the use thereof in the treatment and prophylaxis of inflammatory diseases, are described. 

Macrolides with antiinflammatory activity

Macrolide compounds lacking cladinose in position 3 having antiinflammatory activity and substantially free of antibiotic properties, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them as active ingredient.

Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically acceptable salts thereof and the pharmaceutical composition that contain them as active principle.

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Como, Italy

Andrea Mereu