Jazz Pharmaceuticals, Inc.

Andrea Marie Rourke

Clark Patrick Allphin

Maura Patricia Murphy

James Frederick Pfeiffer

Alya Khan McGinlay

Alya Kahn McGinlay

Alya Khan Mcginlay

The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.

Immediate release formulations and dosage forms of gamma-hydroxybutyrate

The present invention provides a pharmaceutical composition, presented as a solid unit dosage form adapted for oral administration of sodium oxybate. The preferred unit dosage form is a tablet comprising a relatively high weight-percentage of sodium oxybate, in combination with a relatively small weight-percentage of total excipients. This permits the tablets to contain/deliver a pharmaceutically effective amount, e.g., about 0.5-1.5 g of sodium oxybate in each tablet with a delivery profile similar to that of the liquid form. The tablets are bioequivalent to the liquid form.

Immediate release dosage forms of sodium oxybate

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Belmont, CA, United States of America

Andrea Marie Rourke