Becton Dickinson and Company Limited

North Carolina State University

Andrea Liebmann-Vinson

Dwight Livingston

Mark A Talmer

Mohammad A Heidaran

Bryce Chaney

Richard David Guarino

Alexander George Lastovich

Robert E Pearson

James L Schram

Christian Sandmann

W William Stewart

Robert L Campbell

Thomas D Haubert

Jack H Kessler

Ammon David Lentz

Adam C Curry

Kristin Weidemaier

Helen V Hsieh

Rajendra R Bhat

James A Prescott

Michael L Marshall

Gregory S Kramer

Michael Justin Lizzi

Steven Keith

Scott Nicholas Danhof

Melody M H Kuroda

M Scott Ulrich

John Jacob Hemperly

Artis R Lockhart

Eric Fallows

Randy J Somerville

Kevin G Dolan

David S Sebba

Ernie Ritchey

Catherine A Spargo

Donald E Gorelick

Miroslaw Bartkowiak

Wendy Dale Woodley

Spencer Lovette

Jan Genzer

Kirill Efimenko

W Shannon Dillmore

Erin Gooch Carruthers

Jeffrey S Ojala

William Shannon Dillmore

Keith DeLuca

Ruiling Xu

Adam Craig Curry

Eric A Fallows

Melody MH Kuroda

Kirstin Weidemaier

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Assays using surface-enhanced raman spectroscopy (SERS)-active particles

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

The invention provides populations of expanded CD34-expressing cells and methods of use. Particular embodiments provide for defined culture media useful for growing these cells, and grafts comprising these cells. The invention finds use in methods for reconstituting, repairing, and regenerating tissue damage.

Material and methods for the growth of hematopoietic stem cells

The present invention relates to cell adhesion promoting ('CAP') peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant 'CAR'. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.

Peptides for enhanced cell attachment and growth

The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.

Methods of surface modification of a flexible substrate to enhance cell adhesion

Peptides for enhanced cell attachment and cell growth

The invention provides a method and apparatus for determining the presence or absence of respiring cells, involving combining a three-dimensional biomimetic scaffold and cells onto a sensor composition.

Method for determining the presence or absence of respiring cells on a three-dimensional scaffold

Growing community of inventors

Willow Springs, NC, United States of America

Andrea Liebmann-Vinson