Indena S.p.a.

Consiglio Nazionale Delle Ricerche

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (i.r.s.t.) S.r.l.

Andrea Guerrini

Ezio Bombardelli

Arturo Battaglia

Gabriele Fontana

Greta Varchi

Eleonora Baldelli

Anna Tesei

Giovanni Brigliadori

Alessandro Pontiroli

Paolo Dambruoso

Giacomo Carenzi

Donato Pocar

Bruno Danieli

Maria Luisa Gelmi

Cristian Samori

Giovanna Sotgiu

Annalisa Aluigi

Marco Ballestri

Pocar Donato

A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.

Nanoparticles as delivery vehicles of active ingredients and methods for the production thereof

The present invention concerns compounds of general formula (I): Method of preparation and uses thereof. 

Androgen receptor modulating compounds, preparation and uses thereof

The present invention concerns compounds of general Formula (I): method of preparation and uses thereof. 

Non-steroidal compounds for androgen receptor modulation

A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described. 

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III). 

Process for the semisynthesis of deserpidine

A process for the preparation of 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.

Process for the preparation of the 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate

A process for the preparation of paclitaxel starting from 10-deacetylbaccatine III.

Process for the preparation of paclitaxel

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Bologna, Italy

Andrea Guerrini