Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Andrea Geistanger

Johann Karl

Herbert Andres

Michael Tacke

Wolfgang Rollinger

Friedemann Krause

Marie-Luise Hagmann

Norbert Wild

Anton Hilger

Daniel Intelmann

Shirin Shahriari

Nadja Arens

Ursula Garczarek

Michael Pfeffer

A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function ffor a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fdescribes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fis a parametrized function f(concentration), with p=(p,p, . . . p) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)},{circumflex over (p)}, . . . {circumflex over (p)}) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

Method for calibrating at least one mass spectrometry device

A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sis acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.

Method for calibrating at least one analytic device with multiple repeated hardware components

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Munich, Germany

Andrea Geistanger