The University of North Carolina at Chapel Hill

Research Triangle Institute

Andrea Gail Neely

Ginger Denison Rothrock

Leah Marie Johnson

Sarah Dorothy Shepherd

Sandra Cordel O'Buckley

William Maixner

Luda B Diatchenko

Gary D Slade

Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.

Methods and materials for determining pain sensitivity and predicting and treating related disorders

The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.

Formulations for controlled release of bupivacaine

Biocompatible dental putty formulations for controlled release of bupivacaine

Growing community of inventors

Durham, NC, United States of America

Andrea Gail Neely