Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Biogal Gyogyszergyar Rt.

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Teva Gyógyszergyár Zártkörúen Múkó´dó´résvénytársaság

Andrea Csorvasi

Judith Aronhime

Alexandr Jegorov

Vilmos Keri

Ferenc Rantal

Janos Erdei

Eva Gulyas

Gabor Balogh

Peter Seress

Zoltan Czövek

Laszlo Toth

Zsolt Tomas Suto

Ladislav Cvak

Janos Rako

Gyorgyne Mako

Angela Simon

Pavel Blatny

Martin Buchta

The present invention provides a method of preparing and purifying echinocandin-type compounds, such as pneumocandin Bo, WF 11899A, and echinocandin B. These compounds are fermentation products that are used to prepare semi-synthetic products such as the antifungal products Caspofungin, Mycafungin, and Anidulafungin.

Purification processes for echinocandin-type compounds

Provided is a method for obtaining a macrolide, especially tacrolimus, ascomycin, pimecrolimus, sirolimus, or everolimus, from biomatter.

Method for extracting a macrolide from biomatter

Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent at pH of 7 or above.

Crystallization and purification of macrolides

Provided is a method of purifying a macrolide, especially tacrolimus, that includes loading macrolide onto a bed of sorption resin and elting with a suitable eluent such as a combination of water and tetrahydrofuran.

Method of purifying macrolides

The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.

Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth

The present invention is directed to a process of converting lipstatin to orlistat by catalytic hydrogenation. The present invention further discloses novel crystalline solid orlistat forms, designated form I and form II and methods for their preparation.

Preparation of orlistat and orlistat crystalline forms

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Debrecen, Hungary

Andrea Csorvasi