Chiesi Farmaceutici S.p.a.

Andrea Capocchi

Fausto Pivetti

Disclosed is a process for the preparation of sterile aqueous suspensions based on active ingredients in the form of micronised crystalline particles designed for administration by inhalation. In particular, a process for the preparation of sterile aqueous suspensions based on pharmaceutical active ingredients in the form of crystalline hydrates is disclosed.

Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation

The present invention relates to a process for the preparation of inclusion compounds of piroxicam with &#x3b2;-cyclodextrin. More particularly, according to the process of the invention, the aqueous solution of two components is subjected, before drying, to a freezing process at very high rate. The resulting products have physico-chemical characteristics as well as technological and biopharmaceutical properties which are advantageous compared with those obtained according to the prior art processes. The resulting products are suitable for preparing pharmaceutical compositions for the oral administration.

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Parma, Italy

Andrea Capocchi