Celyntra Therapeutics Sa

Danmarks Tekniske Universitet

Andrea Barghetti

Tanya Warnecke

Kurt Marshall

Roland Baumgartner

John Schiel

Alyssa Carlson

Ryan T Gill

Line Dahl Poulsen

Provided herein are nucleic acids useful as guide nucleic acids (gNAs), e.g., guide ribonucleic acids (gRNAs), in a CRISPR system wherein the guide nucleic acids contain one or more modifications to one or more nucleotides, use of such guide nucleic acids in modifying cells, and other uses wherein CRISPR Cas proteins are utilized.

Compositions and methods for targeting, editing, or modifying genes

The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR-Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.

CRISPR systems with engineered dual guide nucleic acids

Growing community of inventors

Copenhagen, Denmark

Andrea Barghetti