Massachusetts Institute of Technology

Zaiput Flow Technologies LLC

Andrea Adamo

Klavs F Jensen

Patrick Louis Heider

Bradley Lether Pentelute

Mark David Simon

Timothy F Jamison

Nopphon Weeranoppanant

Trevor Charles Murray

Jie Chen

Ping Zhang

Allan Stuart Myerson

David R Snead

Jean-Christophe Monbaliu

Torsten Stelzer

Mohsen Behnam

Shin Yee Wong

Robert Viano

Lorenzo Milani

Eve Marie Revalor

Robert Samuel Langer

Armon R Sharei

Dale Arlington Thomas, Iii

Alexander James Mijalis

Robert Langer

Robert S Langer

Kosisochukwu C Aroh

Aaron A Bedermann

Robert Andrew Butters

Alexander P Clayton

Dale Arlington Iii Thomas

The present disclosure is related to the separation of chemical species using multiple liquid phases.

Separation of chemical species using multiple liquid phases and related systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Solid phase peptide synthesis processes and associated systems

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.

Reconfigurable multi-step chemical synthesis system and related components and methods

Reservoir-based management of volumetric flow rates in fluidic systems is generally described. Inventive systems and methods for liquid-liquid separations and/or liquid-gas separations are also described.

Reservoir-based management of volumetric flow rate in fluidic systems

A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.

Intracellular delivery

Pressure control in fluidic systems is generally described. In some cases, a system comprises a fluid-permeable (e.g., liquid-permeable) medium and a pressure regulator. The medium and the pressure regulator can be positioned between a first fluidic channel and a second fluidic channel. The medium is arranged, in certain cases, such that fluid (e.g., liquid) can be transported from the first fluidic channel, through the medium, and into the second fluidic channel. In certain cases, when a first pressure within the first fluidic channel is below a sum of the permeability pressure differential of the medium with respect to the fluid and a second pressure within the second fluidic channel, the fluid is substantially prevented from being transported through an outlet of the first fluidic channel.

Pressure control in fluidic systems

Solid phase peptides synthesis processes and associated systems

Growing community of inventors

Cambridge, MA, United States of America

Andrea Adamo