Other

Andre Schuh

Willem Ouwehand

D Robert Sutherland

Based on the discovery of the nucleotide and amino acid differences which distinguish the Govand Govallelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Govallelic form has Tyr at amino acid position 703 in the CD109 sequence. The Govallelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Govallele to C for the Govallele, in the CD109 gene.

Antibodies for diagnosis and treatment of blood platelet alloimmune disorders

Diagnosis and treatment of blood disorders

The invention is a CD109 nucleic acid molecule and its corresponding polypeptide. The invention also includes biologically functional equivalent nucleic acid molecules and polypeptides. The invention also relates to methods of using these nucleic acid sequences and polypeptides in medical diagnosis and treatment and in drug screening.

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Toronto, Canada

Andre Schuh