Roussel Uclaf

Andre Poittevin

Vesperto Torelli

Andre Allais

Jacques Perronnet

Pierre Girault

Laurent Taliani

Robert Fournex

Pierre Henri Derible

Michel Hardy

A 5-thiazole-methane-amine selected from the group consisting of (1) compounds having the formula ##STR1## wherein R.sub.1 represents an alkyl having from 1 to 6 carbon atoms and R.sub.2 and R.sub.3 represent members selected from the group consisting of hydrogen, alkyl having from 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, and, taken together, alkylene having up to 5 carbon atoms, azaalkylene having up to 4 carbon atoms, alkylalkylene having up to 5 carbon atoms in the alkylene and 1 to 4 carbon atoms in the alkyl, and alkylazaalkylene having up to 4 carbon atoms in the azaalkylene and 1 to 4 carbon atoms in the alkyl which may be in any position, and (2) its acid addition salts with non-toxic, pharmaceutically-acceptible acids; as well as processes for the preparation of the compounds and a process for use of the compounds as an antilipolytic agent.

5-Thiazole-methane-amines, and their use as antilipolytics

Novel 5-thiazole alkanols of the formula ##STR1## wherein R is alkyl of 1 to 5 carbon atoms, n is an integer from 2 to 7 and R.sub.1 is selected from the group consisting of hydrogen and acyl of an alkanoic acid of 2 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a marked antilipolytic activity and useful as intermediates and their preparation.

Hypolipemiant compositions and methods

Novel thiazole derivatives of the formula ##STR1## wherein R is alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of --CH.dbd.CH--, --CH.dbd.CH--CH.dbd.CH-- and (CH.sub.2).sub.n --, n is an integer from 1 to 6 and R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4 and alkali metal, alkaline earth metal and aluminum cations and the non-toxic, pharmaceutically acceptable acid addition salts thereof which have antilipolytic activity and are useful intermediates and their preparation and intermediates produced therein.

Thiazole alkanoic acids, hypolipemiant compositions containing them and

Novel substituted thiazoles of the formula ##STR1## wherein R is alkyl of 1 to 5 carbon atoms and R.sub.1 is selected from the group consisting of --NH.sub.2, -- NH-AlK, ##STR2## PHENYLAMINO AND DIPHENYLAMINO, AlK is alkyl of 1 to 4 carbon atoms and n is an integer from 1 to 6 and their non-toxic, pharmaceutically acceptable acid addition salts having a marked antilipolytic activity and for some of them, a prolonged vasodilatatory activity and an antibradykinetic activity and their preparation.

Novel thiazole derivatives

Novel 2-hydroxymethyl-thiazole-5-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms, benzoyl, phenyl optionally substituted with at least one halogen and ##STR2## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Z is selected from the group of phenyl and phenoxy optionally substituted with at least one halogen and R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and alkali metals, alkaline earth metals and aluminum salts, having a marked hypolipemiant activity as well as a clear vasodilatatory activity and which may possess hypocholesterolemiant activity and their preparation.

2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives

Novel 3-phosphoryloxy-isothiazoles of the formula ##SPC1## Wherein R is selected from the group consisting of alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms and ##EQU1## R' and R' being individually SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL OF 1 TO 3 CARBON ATOMS, R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 12 carbon atoms, cyano, carbalkoxy of 2 to 4 carbon atoms and NHR'', and R'' is selected from the group consisting of hydrogen and aryl of 6 to 10 carbon atoms, R.sub.3 is selected from the group consisting of cyano, alkylthio of 1 to 4 carbon atoms, alkylsulfinyl of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, carbamoyl, carbalkoxy of 2 to 4 carbon atoms and ##EQU2## A and B are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X is selected from the group consisting of oxygen and sulfur which have excellent insecticidal properties.

Certain isothiazolol esters of phosphorus acids

Novel 5-methyl-10-(.beta.-alkylaminoethyl)dibenzo(b,f) azepines of the formula ##SPC1## Wherein R is lower alkyl, R.sub.1 is selected from the group consisting of hydrogen and lower alkyl and X and X' are selected from the group consisting of hydrogen and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having a superior thymoanaleptic activity and their preparation and use.

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Vaires-sur-Marne, France

Andre Poittevin