The Cleveland Clinic Foundation

Andre Machado

Ali R Rezai

Sandra Machado

Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.

Methods of treating medical conditions by neuromodulation of the cerebellar pathways

Method of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation. The method comprises applying a therapy signal to a celiac ganglion, a celiac plexus, a splanchnic nerve, or any combination thereof and adjusting the signal to effectuate treatment. The present invention also provides methods of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation by transluminal modulation of the celiac ganglion, the celiac plexus, the splanchnic nerve.

Methods and systems of achieving hemodynamic control through neuromodulation

Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

Corpus callosum neuromodulation assembly

Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.

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Sao Paulo SP, Brazil

Andre Machado