University of California

Optical Networks, Inc.

International Business Machines Corporation

Andre Knoesen

Nicholas Lawrence Abbott

Richard A Hill

Paul A Feldstein

Bryce William Falk

Joshua Hihath

Erkin Seker

Diego R Yankelevich

Maria Louise Marco

Scott A Hamilton

Gary Bjorklund

Robert Dennis Miller

Robert E Feller

A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.

RNA-based, amplification-free, organism identification using nano-enabled electronic detection

A device, including sample and reference channels through which first and second solutions flow, respectively, the first solution including an analyte, the channels having a metal film in contact with the first and second solutions, the metal film configured with a linker to selectively bind the analyte; a light source whose output is modulated by an optical system, so that light is directed from the optical system alternately towards the sample and reference channels, surface plasmons within the metal film being created; a first photodetector that monitors the strength of the output from the light source; a second photodetector that collects optical signals reflected from the metal film; electronics that monitors output from the first and the second photodetectors, thereby detecting a noise-compensated difference in signals from the two channels; and a computer processor that determines, from analysis of the noise-compensated difference, presence of the analyte in the first solution.

Ultrasensitive biological and chemical detection using surface plasmon resonance

A coplanar waveguide polymeric in-line fiber construct (CPW-PILF) formed on an optic half coupler substrate base or D-fiber wherein the surface is polished down through the cladding on the optical fiber so as to form an evanescent coupling region on the surface. Co-planar, spaced-apart electrodes are deposited on the surface with their gap aligned over the coupling region, and an electro-optic (EO) polymeric waveguide is deposited over the electrodes and between the electrode gap. Light transmitted thorough the optical fiber is evanescently coupled to said waveguide and modulated by a signal applied to the electrodes. Alternatively, the waveguide is deposited on the surface of the substrate and the electrodes are deposited over the waveguide.

In-line polymeric construct for modulators, filters, switches and other

Growing community of inventors

Davis, CA, United States of America

Andre Knoesen