The University of Texas System

Andre F Martins

A Dean Sherry

Sara Chirayil

Veronica Clavijo Jordan

Maria Veronica Clavijo Jordan

In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.

Zinc sensors for in vivo imaging of beta-cell function by MRI

In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.

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Plano, TX, United States of America

Andre F Martins