Institut Pasteur

Andre Dodin

Georgette Le Thuillier

Odile Siffert

Patrice Allard

Bruno Goud

Bernard Muller

Michel Guillou

Eustrate Avrameas

Renee Nicolas

The invention provides a synthetic peptide which reproduces at least 5 of the 11 amino acids common to the .gamma. chain of sub-unit A of cholera toxin and the .gamma. chain of LT toxin of Escherichia coli. It is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): ##STR1## The process of synthesis is by the step by step construction of the peptide chain starting from the C terminal end of said chain, by the successive fixing of the amino acids which constitute the latter. A novel medicament for the treatment of cholera and infectious gastro-enterites comprises said synthetic peptide as active constituent. A diagnosis agent for cholera and/or infectious gastro-enterites comprises a sequence of nucleotides corresponding to the 5 minimum amino acids of the synthetic peptide.

Novel synthetic peptide, process for its preparation and medicaments

A magnetic device is provided for removing magnetic gel balls or the like from a liquid to be analyzed, biological or not, and transferring them to an immunoenzymatic quantitative analysis medium, which device is of the type comprising a ferromagnetic material rod, an oblong case made from a non-magnetic material partially enveloping the rod and a circuit for electromagnetically energizing the rod. The device further comprises structure for fixing and centering the rod by clamping.

Magnetic device for removing magnetic gel balls from a medium to be

The invention provides a synthetic peptide comprising at least 5 of the 11 amino acids common to the .gamma.chain of sub-unit A of the cholera toxin and the .gamma.chain of the LT toxin of Escherichia coli. The peptide is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): ##STR1## The process of synthesis is by the step by step construction of the peptide chain starting form the C terminal end of said chain, by the successive fixing of the amino acids which constitute the peptide. A novel medicament for the treatment of cholera and infectious gastro-enterites is also disclosed which comprises said synthetic peptide as an active constituent. A diagnosis agent for cholera and/or infectious gastroenterites comprises a sequence of at least the 5 amino acids of the synthetic peptide.

A process for the immunobacteriological detection of pathogenic germs possessing specific antigenic determinants, and a kit for carrying out the process, with the aid of a magnetic gel to which are coupled anti-specific antigenic determinant antibodies, characterized by the following steps:

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Milly La Foret, France

Andre Dodin