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Université D'orleans

Les Laboratoires Meram

Les Laboratoires Bruneau & Cie

Laboratoires Sauba S.a.

Andre Buzas

Gilbert Lavielle

Roland Ollivier

Jean-Yves Merour

Jean-Marie Melon

Jacques Bruneau

Andre Champagnac

The invention relates to benzhydryloxyethylpiperidine derivatives corresponding to one of the formulae below: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, represent a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aryloxy group or the trifluoromethyl group,

Benzhydryloxyethylpiperidine derivatives, process for their preparation

The present invention relates to benzhydryloxyethylpiperazine derivatives of the formula: ##STR1## It also relates to processes for the preparation of the said derivatives and pharmaceutical compositions in which they are present. The said derivatives have an antihistaminic activity without a sedative component.

Benzhydryloxyethylpiperazine derivatives, processes for their

The invention relates to 1-[(1,1-diphenyl)-1-alkenyl]piperazine derivatives corresponding to general formula I: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which are identical or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkoxy group or the trifluoromethyl group; n is an integer between 1 and 3; m is an integer from 0 to 3; Z represents a hydrogen atom, a lower alkyl group or an aryl group of the formula: ##STR2## in which R.sub.6 has the same meaning as R.sub.1, R.sub.2, R.sub.3 or R.sub.4 ; and A is an oxygen atom or a group ##STR3## and to their pharmaceutically acceptable salts. Application: pharmeutical compositions with antidepressant properties.

1-[(1,1-diphenyl)-1-alkenyl]piperazine derivatives, method of

This invention relates to the new papaverine carbanion of the formula: ##STR1## and to a preparation process of the same comprising reacting on papaverine, in a solvent, a slight excess of a highly basic agent.

Method of forming a solution of papavrine carbanion

The drug contains an active substance consisting of 1-(3'-benzofuryl)-4-benzylpiperazine. In order to prepare the compound, a reaction is carried out with reflux between 3-coumaranone and N-benzylpiperazine in the presence of acetic acid and in an aromatic solvent.

Analgesic drug containing a derivative of benzylpiperazine

Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral

The disubstituted 2,5-benzamides correspond to the following general formula: ##STR1## where R is an alkyl group (possessing 1 to 5 carbon atom) or an allyl group, ##STR2## represents one of the following groups: phenylpiperazine, benzylpiperazine, piperonylpiperazine, dimethylaminoethylamino, diethylaminoethylamino, pyrrolidinyl-1 substituted methylamino, morpholine or piperidine, R' is an alkyl possessing 1 to 8 carbon atoms, a phenyl, or substituted phenyl, an alpha-aminomethyl or acrylic group, Y is an oxygen atom, an oxime, oxime ether, oxime ester or imine group.

Disubstituted 2,5-benzamides and pharmaceutical compositions containing

1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES HAVING THE FORMULA ##STR1## wherein R is C.sub.1-3 alkyl, halogen or hydrogen; R.sub.1 is phenyl or C.sub.1-3 alkyl; R' is hydrogen when R.sub.1 is alkyl and is the same as R when R.sub.1 is phenyl; R.sub.2 is hydrogen or C.sub.1-3 alkyl; n is 2-4; n' is 1-4; and A is a group comprising a trivalent organic function which may be acid, ester, nitrile or amide, in which latter case the nitrogen of the amide is part of the ring, and more particularly COOH, COONa, COOCH.sub.3 or COOC.sub.2 H.sub.5. These derivatives or their addition salts with pharmaceutically acceptable acids, have high psychostimulating activity.

Non-amphetaminic psychostimulating compositions of 1,4-disubstituted

The invention relates to 1-methyl-2-(m-trifluoromethylphenyl)-ethylamide of p-pentylaminophenoxyacetic acid and its pharmaceutically acceptable acid addition salts which have outstanding anorexigenic properties.

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Bievres, France

Andre Buzas