Battelle Memorial Institute

Intracel Corporation

Andre Bregnard

John F Place

Georges Revillet

Claus Dahne

Ranald M Sutherland

A mould for the casting of thin, cross-linked, polymerized resin films is subjected, when being filled with the liquid to be polymerized, to a centrifugal force field exceeding that of the earth gravitation field, the whole being for equalizing the intimate structure of the polymer and to expel therefrom the bubbles of gas possibly present therein. After curing the gel, a mixture of compounds to be separated by the application of an electric field is introduced into the gel and the latter is subjected to electrophoresis within the mould itself.

Apparatus for casting thin layer gel media in a mould and subsequently

Waveguide apparatus for use in substance analysis has a waveguide, with a surface area in contact with the substance, for transmitting electromagnetic radiation along the axis of the waveguide whereby propagation characteristics of the radiation are altered in accordance with properties of the substance adjacent the waveguide. A waveguide entrance prism is positioned at the radiation entrance end of the waveguide, for guiding radiation into the waveguide. The prism has a first face arranged at an angle with the waveguide axis to cause radiation entering the prism to propagate along the waveguide. In one embodiment, a longitudinal partition is arranged adjacent the waveguide substantially parallel to the waveguide axis, for partitioning the waveguide surface area into at least two parts so that multi-substance analysis can be carried out. In another embodiment, the waveguide entrance prism includes a first face perpendicular to the waveguide axis, and second and third faces at an angle to both the waveguide axis and the first face. In effect, two entrance prisms are provided in the second embodiment. The second embodiment also includes a reflector and filter at the distal end of the waveguide to filter and reflect radiation back to the entrance prism.

Waveguide to be used as optical probe in multiple internal reflection

This apparatus comprises a magazine (18) of moulds (10) a device (50) for grasping these moulds and allowing each mould to be brought sucessively above a support (30), then above an electrophoretic cell (40). A pipetting device (20, 23) allows each mould placed on the support (30) to be filled with an electrically conductive gel and a mixture of components to be separated by electrophoresis to be introduced thereinto. Thanks to a device (70) it is possible to decelerate and measure, during electrophoresis, the relative positions of the components of the mixture and their velocity of separation in the gel.

Apparatus for separating a mixture of components by thin layer

A mould for the moulding by casting of thin, cross-linked, polymerized resin films is used which is subjected, when being filled with the liquid to be polymerized, to a centrifugal force field exceeding that of the earth gravitation field, the whole being for equalizing the intimate structure of the polymer and to expel therefrom the bubbles of gas possibly present therein.

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Le Lignon, Switzerland

Andre Bregnard