Sanofi

Elf Sanofi

Andre Bousquet

Alain Heymes

Jean-Robert Dormoy

Michel Bouisset

Christian Forqlly

Serge Calet

Composition consisting of a mixture of (E) and (Z) isomers of esters of general formula: ##STR1## in which R represents a C.sub.1 -C.sub.4 alkyl radical, containing at least 85% of (E) isomer. A process for preparing such a composition. The use of such a composition for preparing (E)-2-propyl-2-pentenoic acid of formula: ##STR2## and also its pharmaceutically acceptable salts.

Process for preparing (E)-2-propyl-2-pentenoic acid and intermediate

The invention relates to isopropyl 2-thienylglycidate of formula: ##STR1## obtained by reaction of 2-thienylcarboxaldehyde with an isopropyl haloacetate. It is employed as a synthesis intermediate in the preparation of 2-thienylacetaldoxime and of medications derived from thieno[3,2-c]pyridine.

2-thienylglycidic derivative, process for its preparation and its use as

The object of the invention is a process for the preparation of the trans(-) (2R,3S) diastereoisomer of the glycidic esters of general formula: ##STR1## wherein a chlorohydrin of general formula: ##STR2## is reacted with a strong organic base in a suitable solvent and at a temperature between -10.degree. C. and room temperature. Another object of the invention is intermediate compounds cis(+) (2S,3S) 1,5-benzothiazepin-4-one.

Process for the preparation of benzothiazepin-one derivatives

The subject of the present invention is a process for the preparation of isoquinoline derivatives in four steps wherein use is made as synthetic intermediates of organo-lithium compounds or related compounds.

Process for the preparation of isoquinoline derivatives

The invention relates to the preparation of di-n-propylacetonitrile, according to a process consisting in heating N-(1-propyl-n-butyl)formamide to a temperature of between 350.degree. C. and 550.degree. C. and in the absence of oxygen, in the presence of a catalyst consisting of a silica impregnated with 0.1 to 10% by weight of alkali metal cations.

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Sisteron, France

Andre Bousquet