Richter Gedeon Vegyeszeti Gyar Rt

Egyt Gyogyszervegyeszeti Gyar

Richter Gedeon Vegyeszeti Gmbh

Andras Vedres

Csaba Szantay

Bela Stefko

Janos Kreidl

Egon Karpati

Bela Kiss

Gabor Blasko

Erik Bogsch

Andras Nemes

Istvan Hegedus

Tamas Mester

Denes Mathe

Istvan Moldvai

Laszlo Szporny

Eva Palosi

Laszlo Czibula

Erzsebet Lapis

Sandor Farkas

Zsolt Szombathelyi

Dora Groo

Aniko Gere

Adam Sarkadi

Maria Zajer Nee Balazs

Ferenc Auth

Maria Incze

Gyula Balogh

Maria Vedres Nee Kozma

Maria Farkas Nee Kiriak

Adrien Szuchovszky Nee Gergely

Miklos Riesz

Margit Pellionisz Nee Paroczai

Andras Szekeres

Adrien Szuchovszky, Nee Gergely

Ida Deutsch Nee Juhasz

Karoly Thuranszky

Trans apovincaminic acid ester derivatives

The invention relates to a new process for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula (I), ##STR1## which comprises reacting a pyrimidine derivative of the general formula (II), ##STR2## wherein R.sub.1 stantds for hydrogen or a ##STR3## group, wherein R means a C.sub.1-6 alkyl group or an aryl group optionally substituted by halogen;

Preparation of

The invention relates to a new process for preparing novel racemic and optically active 9- or 11-nitroapovincaminic acid derivatives of the general formula (I) ##STR1## wherein R stands for a --CO--X group, wherein X means a halogen atom; or

Nintrovincaminic acid derivatives having pharmaceutical utility

A pyrimidine derivative of the formulae (Ia), (Ib) and (Ic), ##STR1## wherein R stands for an alkyl group group with 1 to 6 carbon atoms or an aryl group optionally substituted by halogen atom; and

Pyrimidine derivatives and process preparing the same

Novel 2-hydroxyimino-1,2,3,4,6,7-hexahydro-11bH-benzo [a] quinolisine derivatives are prepared by reacting substituted 2-oxo-benzo[a]quinolisine compounds with hydroxylamine or an acid addition salt thereof. The described compounds and their acid addition salts and quaternary onium derivatives evidence psychopharmacological properties in the absence of adverse side effects.

2-Hydroxyimino-1,2,3,4,6,7-hexahydro-11bH-benzo [a] quinolisine

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Budapest, Hungary

Andras Vedres