Eotvos Lorand Tudomanyegyetem

Printnet Kereskedelmi És Szolgáltató Kft.

Behr Gmbh Co. Kg

Prosidion Limited

Avidin Co. Ltd.

Soneas Research Co. Ltd.

Synaging Sas

Galimedix Therapeutics Inc.

András Szabó

József Répási

Sándor Bátori

Mihály Kovács

Ádám István Horváth

Máté Pénzes

Péter Hári

Zoltán Simon

András Málnási-Csizmadia

László Végner

Suthar Sharad Kumar

Gyula Tóth

József Mercz

István Lörincz

Zoltán Szönyegi

Vajk Horváth

Máté Gyimesi

Markus Henrich

Márió Gyuris

Jozsef Repasi

István Kanizsai

Ferenc Takács

Maté Gyimesi

Hermann Kurt Russ

László Hackler

Vajik Horváth

László Puskás

Thierry Pillot

István Lórincz

Zoltán Szónyegi

Ádám István HORVÁTH

The present invention relates to compounds of formula (I) or (II) pharmaceutically acceptable salts, solvates, tautomers, stereoisomers thereof, including enantiomers, diastereomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, and pharmaceutical uses of the compounds.

Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms

This intention relates to a novel polymorph form of compound (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid, a process for making the novel polymorph form of the compound, and uses thereof for making other polymorph forms of the compound. The invention further relates to composition comprising novel polymorph form of the compound and a pharmaceutically acceptable carrier or excipient.

Polymorph form of (r)-2-[2-amino-3-(indol-3-yl)propionylamino]-2- methylpropionic acid and uses thereof

Our invention relates to novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and pharmaceutically acceptable salts and metal complexes thereof, and the medicinal and/or pharmaceutical compositions comprising these compounds.  The essence of the subject matter of the invention relates to the fact that prior art discloses the biological effect and characteristics only of the racemic products, the novel enantiomer derivatives according to the invention appear in our application for the first. The subject matter of the invention furthermore relates to a novel, stereoselective synthesis for the preparation of the novel enantiomer derivatives according to the invention. The novel medicinal and/or pharmaceutical compositions comprising these enantiomers are suitable for the treatment of the named diseases, and the enanatiomers are used for manufacture of these compositions. These applications for manufacture of the compositions are also the subject matters of the invention. The compounds according to the invention can be used preferably as cytoprotective, neuroprotective, cardioprotective, anxiolytic and antidepressant agent for treatment of neuropsychiatric and neurologic diseases and diseases in connections with transplantations and with ischemia and reperfusion injuries thereof, and inhibition of organ, advantageously skin graft rejection. According to our studies the R-enantiomer has either sole or high biological effect in some cases.

Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof

The present invention is directed to a novel form of a pyrrolopyridine-2-carboxylic acid amide of formula (I), which is an inhibitor of glycogen phosphorylase, compositions containing it and their use in therapy. The invention is also directed to processes for production of the novel form, novel intermediates used in said processes and processes for the production of said intermediates.

Pyrrolopyridine-2-carboxylic acid amide derivative useful as inhibitor of glycogen phosphorylase

A switchable exhaust gas heat exchanger includes an exhaust gas feed line and an exhaust gas discharge for an exhaust gas stream; a first exhaust gas passage and a second exhaust gas passage; a switching valve configured to switch the exhaust gas stream between the first and second exhaust gas passages; and a heat exchanger through which a coolant flows which is arranged in the first exhaust gas passage. The second exhaust gas passage routes the exhaust gas stream past the heat exchanger to the exhaust gas discharge. The switching valve is configured to be switched as a function of the temperature of the coolant and is a proportional control valve. A switching threshold and a switching limit of the coolant determine flow of the exhaust gas stream through the first and second exhaust gas passages.

Switchable waste gas exchanger

A switchable waste gas heat exchanger which can be arranged and used in exhaust gas recirculation lines in internal combustion engines, such as in motor vehicles.

Growing community of inventors

Budapest, Hungary

András Szabó