Richter Gedeon Vegyeszeti Gyar Rt

Robert Bosch

Andras Nemes

Janos Kreidl

Csaba Szantay

Gyorgy Kalaus

Laszlo Czibula

Lajos Szabo

Maria Farkas Nee Kirjak

Istvan Hegedus

Bela Stefko

Gyorgy Visky

Gabor Blasko

Erik Bogsch

Janos Sapi

Andras Vedres

Eva Werkne Papp

Denes Mathe

Tamas Mester

Ida Deutschne Juhasz

Kalman Harsanyi

Janos Fischer

Katalin Nogradi

Laszlo Dobay

Istvan Borza

Judit M Meszaros Nee Brill

Ida Deutsch Nee Juhasz

Judit Nagyne Bagdy

Zsuzsanna Aracs Nee Tischler

Bela Benke

Peter Mihaly Vas

Adrien Szuchovszky, Nee Gergely

Albert Meszaros

Viktor Imre

Peter Meszaros

Csaba Juhasz

Adrien Szuchovszky Nee Gergely

Maria Farkas Nee Kirlyak

Laszlo Cibula

Kalmam Gaf

Katalin Horvath Nee Berki

Kalman Graf

Ildiko Ballo

Jen&ouml;me Farkas

Lajos Szaho

Istvan Heged&uuml;s

Juidit Nagyne Bagdy

Methods for testing a control unit of a vehicle. The control unit obtains calculated surrounding-area data of a simulated surround sensor, and obtains calculated motion data of a simulated vehicle. The calculated motion data are transmitted to the control unit via a simulated vehicle data bus. Using a sensor testing unit, the calculated surrounding-area data are transmitted to the control unit via a sensor-data transmission circuit different from the vehicle data bus. To execute a simulated acquisition of surrounding-area data, using the control unit, a command for executing a measurement is transmitted to the sensor testing unit, data for identifying the position of the simulated surround sensor is transmitted to the computer device, positions of points of reflection by simulated objects in the surrounding area of the vehicle are calculated and transmitted to the sensor testing unit, and calculated surrounding-area data are determined and transmitted to the control unit.

Method and system for testing a control unit of a vehicle

Process for the synthesis of a known tetrazol derivative

N-benzylpiperidine and tetrahydropyridine derivatives

New intermediate compounds are disclosed of the formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl having 1 to 4 carbon atoms, or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid residue, and a process for the preparation of the intermediate compounds.

Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl

The invention relates to a new process for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula (I), ##STR1## which comprises reacting a pyrimidine derivative of the general formula (II), ##STR2## wherein R.sub.1 stantds for hydrogen or a ##STR3## group, wherein R means a C.sub.1-6 alkyl group or an aryl group optionally substituted by halogen;

Preparation of

A pyrimidine derivative of the formulae (Ia), (Ib) and (Ic), ##STR1## wherein R stands for an alkyl group group with 1 to 6 carbon atoms or an aryl group optionally substituted by halogen atom; and

Pyrimidine derivatives and process preparing the same

A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) ##STR1## and the corresponding optically active derivatives of the formulae (Ia) ##STR2## wherein R.sup.1 and R.sup.2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.

Apovincaminic acid esters

The invention relates to a new process for the preparation of eburnamonine derivatives of the general Formula I ##STR1## (wherein R.sup.1 is an alkyl group having 1-6 carbon atoms) and optical and geometrical isomers thereof which comprises reacting a hydroxyimino-octahydro-indolo[2,3-a]quinolizine derivative of the general Formula II ##STR2## (wherein R.sup.1 is as stated above and R.sup.2 stands for an alkyl group having 1-6 carbon atoms being identical with or different from R.sup.1, or a hydrogen atom) or an acid addition salt thereof in an organic protic solvent or solvent mixture with an inorganic base, optionally under the addition of water or an aqueous mineral acid, at a temperature between 60.degree. C. and 200.degree. C. The compounds of the present invention are known drugs having blood pressure decreasing and cerebral vasodilatatory effect. The advantage of the process of the present invention is that it is readily feasible on industrial scale too, provides isomer-free pure products with high yield and requires the use of readily available simple starting materials.

Process for the preparation of eburnamonine derivatives

The invention relates to a new process for the preparation of apovincaminic acid esters. More particularly, the invention concerns a process for preparing racemic and optionally active vincaminic acid esters of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 independently stand for alkyl having from one to 6 carbon atoms, and 14-epimers thereof. According to the invention an octahydroindolo[2,3-a]quinolizine-oxime ester of the formula (II) ##STR2## in which R.sup.1 and R.sup.2 have the same meaning as defined above, is reacted with an aqueous solution of sulfurous acid or a salt thereof at a temperature of 80.degree. to 110.degree. C. and the 14-epimeric mixture obtained is epimerized or separated in a known manner and if desired, the racemic vincaminic acid esters are resolved. The valuable, pharmaceutically active compounds of the formula (I) can be prepared according to the invention in a considerably improved yield and the undesired side reactions can be suppressed and/or the by-products can easily be converted into other pharmaceutically active materials.

Process for the preparation of vincaminic acid esters

The invention relates to a new enantioselective synthesis for the preparation of optically active 14-oxo-E-homo-eburnane derivatives of the formula (Ia) ##STR1## wherein R.sup.1 is alkyl having from 1 to 4 carbon atom. In the synthesis optically active 6-alkoxycarbonylhexahydroindoloquinolizinium salts are employed as starting materials, which contain a center of chirality at the site of attachment of the carboxyl group. This center of chirality preserves the optical activity of the optically active tryptophan ester from which this compound has been prepared until a new center of chirality is formed in the molecule in a configuration corresponding to the desired end product. The carboxyl group, which is not needed in the end product and only serves to preserving the optical activity can then be eliminated. Compounds of the formula (Ia) are known in the art and may be used in the synthesis of (+)-vincamine and (+)-apovincaminic acid ethylester.

Process for an enantioselective synthesis of optically active

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Budapest, Hungary

Andras Nemes