Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Andras Muhlrad

Michael Chorev

Itai A Bab

Dan Gazit

Arie Shteyer

Chen Yu-Chen

Nura Mansur

Zvi Greenberg

Gideon A Rodan

Shimon Slavin

John W Jacobs

Olga Gurevitch

Arye Shteyer

Mohinder K Sardana

Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same

The invention relates to synthetic pseudopeptide derivatives of osteogenic grog polypeptide (OGP) and OGP(10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

Osteogenic growth oligopeptides and pharmaceutical compositions

A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino acid sequence of

Osteogenic growth polypeptides identified from regenerating bone marrow

Growing community of inventors

Jerusalem, Israel

Andras Muhlrad