Hangzhou Jitai Pharmaceutical Technology Co., Ltd.

China Aerospace Corporation and Beijing Normal University

Beijing Jitai Pharmaceutical Technology Co., Ltd.

Andong Liu

Lin Zhang

Liu Yang

Caida Lai

Yiming Yan

Wenshou Wang

Dachun Wang

Yejun He

Baozhen Chen

Xunliang Ding

Fuzhong Wei

Provided herein is a class of ionizable lipid compounds represented by formula (IV), or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Ionizable lipid compounds

A method for manufacturing the monolithic capillary X-ray lens, comprising the steps of Drawing a hollow glass raw-tube into monocapillaries in a heating furnace by a drawing tower; Stacking monocapillaries into a symmetric mould to form a multibundle; Feeding the multibundle into the heating furnace to be heated at uniform speed or variable speed; Drawing the multibundle by a drawing tower at uniform speed and variable speed to form a first integrated lens billet; Cutting the monolithic lens billet into desired shape according to usage to form said first monolithic capillary X-ray lens. A monolithic capillary X-ray lens produced by using said method comprises a plurality of X-ray channels passing from one end through another end, and is a single glass solid formed by melting together the walls themselves of said X-ray channels. An X-ray diffractometer employing said lens comprises an X-ray source, a sample, a detector, a high voltage power supply, an amplifier, a pulse analyzer, a scaler, a ratemeter, a computer, an X-ray source control system and a goniometer, wherein the monolithic capillary X-ray lens are disposed between the X-ray source and the sample and/or between the sample and the detector.

Method for manufacturing monolithic capillary X-ray lens, a monolithic

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Beijing, China

Andong Liu