Astrazeneca Ab

Dr. Reddy's Laboratories, Incorporated

Astazeneca Ab

Andiappan Murugan

Maurice Raymond Verschoyle Finlay

Richard Andrew Ward

Heather Marie Redfearn

Claudio Edmundo Chuaqui

Sam Butterworth

Vasantha Krishna Kadambar

Anna Kristoffersson

Peter Olof Sjö

Maurice Raymond Finlay

Chandrasekhara Reddy Chintakuntla

Lena Kristina Bergstrom

Martin Lindsjö

Rama Rao Gondu

Shravankumar Chandrashekar

Krishnamoorthy Pasupathy

Anandan Kalaiselvan

Chinna Saida Reddy Gade

Vipinkumar Shriram Kabra

Mark David Ashton

Jon Meigh

The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

2-(2,4,5-substituted-anilino)pyrimidine compounds

The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m/g.

Process for preparation of palbociclib

The invention provides compounds of formula wherein R, R, R, R, R, R, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

2-pyridone compounds

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Bengaluru, India

Andiappan Murugan