Gambro Lundia Ab

Anders Wallenborg

Thomas Hertz

Jan P Sternby

Anders Nilsson

Kristian Solem

Mattias Holmer

Per Hansson

Lennart Jönsson

Paolo Rovatti

Carlo Alberto Lodi

Alessandro Surace

Johan Andersson

Bo Olde

Olof Jansson

Sture Hobro

Mauro Suffritti

Roger Nilsson

Roy Sven Hovland

Björn Ericson

Henrik Lindgren

Jonas Fors

Annmargret Håkansson

Pietro Masala

Thomas Gebhart

Annmargret HÅKANSSON

A system and a method for renal replacement therapy includes a blood treatment unit connected to a blood circuit and a dialysis fluid circuit, the system further including a control unit configured to control the system according to control instructions during a treatment, so as to determine a system parameter value and an indication of membrane fouling of the membrane, and activate an automatic anti-fouling measure that includes a temporary change of the flow rate in the blood circuit and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

System and a method for renal replacement therapy

An extracorporeal blood treatment apparatus includes a filtration unit () connected to a blood circuit () and a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.

Apparatus for extracorporeal blood treatment

A blood treatment apparatus is disclosed. The example apparatus includes a blood treatment unit including a fluid inlet and a fluid outlet and a blood line. The apparatus also includes a fluid line including an upstream fluid line configured to receive electrically conductive treatment fluid from a fluid source and pass the electrically conductive treatment fluid to the fluid inlet of the blood treatment unit and a downstream fluid line connected to the fluid outlet of the blood treatment unit for delivering the used electrically conductive treatment fluid to a fluid sink. The apparatus further includes a flow divider arranged in the downstream fluid line and configured to separate the used electrically conductive treatment fluid in the downstream fluid line into to a first fluid section and a second fluid section, thereby electrically isolating the first and second fluid sections.

Blood treatment apparatus including flow divider for limiting an electrical current

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid; a control unit () is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line () at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

A blood treatment apparatus is disclosed. In an example, the blood treatment apparatus includes a blood treatment unit; a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel; and a fluid line configured to pass treatment fluid through the blood treatment unit and deliver used treatment fluid to a fluid sink. A flow divider is arranged in the fluid line for separating treatment fluid into to a first fluid section and a second fluid section, thereby electrically isolating the fluid sections such that electrical current flowing in the fluid line between the fluid sections is limited. Related manufacturing and verification methods are also described.

A monitoring device operates on a pressure signal from a blood processing apparatus which has an extracorporeal blood circuit for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device has a first input block for obtaining a first pressure signal, and a second input block for obtaining a second pressure signal. An emulation block generates, as a function of the second pressure signal, an emulated first pressure signal which emulates a concurrent signal response of the first pressure sensor, and a filtering block generates a filtered signal as a function of the first pressure signal and the emulated first pressure signal, so as to suppress, in the filtered signal compared to the first pressure signal, signal interferences originating from the treatment fluid supply system. A pulse detection block processes the filtered signal for detection of subject pulses.

Detecting pressure pulses in a blood processing apparatus

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

A blood treatment apparatus comprising: a blood treatment unit; a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel; and a fluid line configured to pass treatment fluid through the blood treatment unit and deliver used treatment fluid to a fluid sink. A flow divider is arranged in the fluid line that separates treatment fluid into a first fluid section and a second fluid section, thereby electrically isolating the fluid sections such that electrical current flowing in the fluid line between the fluid sections is limited. Related manufacturing and verification methods are also described.

Blood treatment apparatus with flow divider for limiting an electrical current

Extracorporeal blood treatment apparatus having dialysis fluid parameter data entry

A monitoring device () operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device () has a first input block () for obtaining a first pressure signal (y) from a first pressure sensor () in the extracorporeal blood circuit, and a second input block () for obtaining a second pressure signal (w) from a second pressure sensor () in the treatment fluid supply system. An emulation block () generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (), and a filtering block () generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (). A pulse detection block () processes the filtered signal (y) for detection of subject pulses originating from the subject.

In a hemodiafiltration apparatus, a control and command unit () halts a replacement fluid supply pump () and contemporaneously modifies the control mode of a blood pump () passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor () arranged downstream of a hemodiafilter (). The aim is to prevent risks due to excessive hemoconcentration in the blood circuit between the ultrafiltration zone and the infusion zone.

Hemodialysis or hemo(dia)filtration apparatus and a method for controlling a hemodialysis or hemo(dia)filtration apparatus

A blood treatment apparatus, including a blood treatment unit configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps configured to pass blood treatment fluid through the blood treatment unit, a pair of blood pumps configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel, each blood pump including a pump chamber and a flexible member separating the pumping chamber into a first blood accumulating container and a second working fluid accumulating container where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. A control unit and a measuring device are configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers whereby the pumped mass or volume of working fluid is determined by the control unit at an arbitrary position of the flexible member.

Blood treatment apparatus and method

A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter is determined based on a difference between (i) a first amount of fresh blood treatment fluid received into the blood treatment unit, and (ii) a second amount of used blood treatment fluid emitted from the blood treatment unit during another well-defined period.

A blood treatment apparatus () comprising a degassing unit () receiving gas-containing fluid and supplying degassed fluid to a fluid chamber () of a blood treatment unit (). The degassing unit has a gas separator (), a degassing pump () to circulate fluid in a degassing line (), a flow restrictor () for reducing the pressure in the degassing line (), an absolute pressure sensor (), and a control unit () designed to control the speed of said degassing pump from the absolute pressure signal emitted by the pressure sensor. The apparatus comprises a dialysis machine provided with a device for preparing on-line a dialysis liquid from water and concentrates. The apparatus achieves an accurate and reliable regulation of a desired concentration of gas in the dialysis liquid.

Growing community of inventors

Bjärred, Sweden

Anders Wallenborg