Kabivitrum Ab

Pharmacia Ab

Pharmacia & Upjohn Ab

Anders Strom

Ebba Florin-Robertsson

Bo Ahlstrand

Birger T Hjertman

Birger Hjertman

Linda Fryklund

Olle Ljungquist

Gustav Levander

Elvy Hokby

Karin Limrell

Ulf Nilsson

Marie-Louise Gustavsson

Jacob Kaluski

Jonas Virding

The invention relates to a one-dose syringe comprising a first chamber with a freeze-dried composition comprising a protein in an amount of less than 1.4 mg, amino acid and stabilizer where the weight ratio between protein and amino acid versus stabilizer is less than 1.5 and in which the ratio of the weight of the dry component versus the cake volume in the first chamber is above 12 mg/ml, and a second chamber with an aqueous reconstitution solution with an injectable volume of less than 0.5 ml.

Syringe

Method and device for dosing a liquid preparation

Combined medical syringe and vial for administering subcutaneous

Medical syringe for administering subcutaneous injections

A dual-chamber cylinder ampoule is used for the mixture of a sensitive, solid medicament, with liquid which is caused to flow calmly through the medicament in order to avoid any shaking and mechanical influence. The mixing is preferably carried out at a pressure above atmospheric. An injection device for the preparation of an injection solution and a following injection of such solution includes first and second tubular members for enclosing and holding a dual-chamber cylinder ampoule, in which the dry medicament is kept separated from the liquid. When the two tubular members are being screwed together the liquid is calmly and gently mixed with the dry medicament and dissolves it, and the resulted solution can thereafter be injected by means of the dosage and administration mechanism, provided in one tubular member, through a needle arranged at the front end of the other tubular member.

Method and device for injection

Growing community of inventors

Enskede, Sweden

Anders Strom