Vicore Pharma Ab

Personal Chemistry I Uppsala Ab

Labwell Ab

Anders Rudolf Hallberg

Mathias Alterman

Mats Larhed

Xiongyu Wu

Bengt Ohlsson

Tomas Fex

Nils-Fredrik Kaiser

Ulf Bremberg

Murugaiah Andappan Murugaiah Subbaiah

Christina Moberg

Gunnar Lindeberg

Nadia Nasser Petersen

There is provided pharmaceutical compounds of formula I, wherein R, R, R, R, R, R, Y, Y, Y, X and Z have meanings given in the description, which compounds are useful in the treatment of autoimmune and/or fibrotic diseases, including interstitial lung diseases, such as idiopathic pulmonary fibrosis and sarcoidosis.

Selective angiotensin II compounds

There is provided a compound of formula I, wherein R, R, X, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Bicyclic angiotensin II agonists

There is provided compounds of formula (I), wherein X, X, X, Y, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Tricyclic compounds useful as angiotensin II agonists

There is provided compounds of formula I, wherein A, X, X, X, X, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Tricyclic angiotensin II agonists

There is provided compounds of formula I, wherein the dotted line, X, X, X, A, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.

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Stockholm, Sweden

Anders Rudolf Hallberg