Nycomed Imaging As

Anders Olsson

Robertson Towart

Per Jynge

Jan Olof Gustav Karlsson

Helge Refsum

Tudor Griffith

Derek Grant

Rolf Goran Gustav Andersson

Bo Zieden

The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R,independently represents hydrogen or &mdash;CH,COR,; R,represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R,independently represents a group XYR,; X represents a bond, or a C,alkylene or oxoalkylene group optionally substituted by a group R,; Y represents a bond, an oxygen atom or a group NR,; R,is a hydrogen atom, a group COOR,, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR,, CONR,, NR,, OR,, &boxH;R,, &boxH;O, OP(O)(OR,)R,and OSO,M; R,is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R,is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R,represents a C,alkylene group, preferably a C,, e.g. a C,alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R,independently represents hydrogen or C,alkyl; and each R,independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).

Use of chelating agents in the treatment of atherosclerotic conditions

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Vreta Kloster, Sweden

Anders Olsson