Zymeworks Inc.

National Research Council of Canada

Nanogrid Limited

Anders Ohrn

Scott Paul MacDonald

Yi Guo

Surjit Bhimarao Dixit

Tomas Rodinger

Gordon Yiu Kon Ng

Paula Irene Lario

Eric Escobar-Cabrera

Maureen D O'Connor-McCourt

Jason Baardsnes

Stacey A L Tom-Yew

Adam Louis Corper

Yang-Chieh Chou

Gregory Lakatos

David K Y Poon

Antonios Samiotakis

Igor D'Angelo

Dustin Bleile

Gordon Yiu Ng

Maureen O'connor-Mccourt

Scott Paul Macdonald

Stacey A Tom-Yew

David K Poon

Igor D'angelo

Surjit B Dixit

Maureen O'CONNOR-Mccourt

Embodiments of the present disclosure generally relate to the field of electronic data communications, and more specifically to transport methods for hierarchical data networks in relation to providing 'address-less data transport' of data packets. An order is introduced or associated with nodes to establish relationships, and the order may be stored in the form of a tree topology in a data structure. The order of nodes is thus known, and logic and/or other data sets, data payloads, etc., may be transmitted across the nodes, wherein the steps to execute the transmission are more efficient due to the properties of the ordered nodes. Each node in the plurality of nodes is comprised of a plurality of network interfaces, which through pairwise joining, forms a data network of a tree topology.

Transport method in hierarchical data network

The invention provides a computer implemented method of quantifying the quality of packing for a residue comprising one or more residue atoms in a first protein in a first conformation, the method comprising: (a) calculating one or more close contact potentials based on a distance between the one or more residue atoms and one or more environment atoms, (b) calculating a contact area of the one or more residue atoms that is exposed to the one or more environment atoms and (c) calculating a close contact surface density (CCSD) by dividing the sum of the one or more close contact potentials by the contact area.

System for molecular packing calculations

Systems and methods for visualization of a molecule, comprising a set of particles, are provided. A set of three-dimensional coordinates is obtained, each coordinate describing a position for a corresponding particle. A cost function containing an error in a set of two-dimensional coordinates, where each two-dimensional coordinate corresponds to a three-dimensional coordinate in the set of three-dimensional coordinates, is minimized until an exit condition is achieved. The minimization alters the two-dimensional coordinate values. A set of physical properties Sis obtained, each such property representing a property shared by a pair of particles in the molecule. The coordinates are plotted as nodes of a two-dimensional graph after minimization, connected by a plurality of edges. An edge connects a coordinate pair in the graph that corresponds to a pair of particles in the molecule. A characteristic of the edge is determined by a physical property for the pair of particles.

Systems and methods for making two dimensional graphs of complex molecules

The invention provides a method of determining changes in a first set of residues rdue to changes in a second set of residues rin a protein system comprising one or more proteins comprising rand r. In exemplary embodiments, the method comprises optimizing a quality function Q by modifying one or more properties of rand rin a constrained environment in which all degrees of freedom of the system except those directly involved in the potential coupling between rand rare removed.

Simplifying residue relationships in protein design

Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.

Methods of quantitating heavy and light chain polypeptide pairs

Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.

Antibodies with enhanced or suppressed effector function

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Toronto, Canada

Anders Ohrn