H. Lundbeck A/s

Aarhus Universitet

Anders Nykjær

Simon Glerup Pedersen

Karen-Marie Pedersen

Claus Munck Petersen

Kimmo Jensen

Olav Michael Andersen

Ulrich Bølcho

Ole J Bjerrum

Christian Bjerggaard Vægter

Pernille Jansen

Peder Søndergaard Madsen

Simon Glerup

Michael Olav Andersen

Ole Bjerrum

Ditte Olsen

The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention further-more relates to methods of altering expression of said receptors in vivo.

Modulation of the Vps10p-domain receptor family for the treatment of mental and behavioural disorders

This invention relates to the use of an agent capable of binding and thus inhibit formation of a binary Vps10p-domain receptor:TrpV receptor complex, and/or formation of a further ternary Vps10p-domain receptor:TrkA:TrpV receptor complex for the preparation of a medicament for the inhibition of pain and pain signalling through said complex(es). The invention is thus beneficial in the preparation of a medicament for the treatment and/or prevention of neuropathic pain, chronic pain and acute pain. The invention furthermore relates to the identification of such agents and animal models for screening for such agents.

Modulation of the TrpV: Vps10p receptor system for the treatment of pain

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Risskov, Denmark

Anders Nykjær