Astrazeneca Ab

Astra Aktiebolag

Astrazenca Ab

Nps Pharmaceuticals, Inc.

Stayble Therapeutics Ab

Thomas M. Stormann

Jan Mattsson

Anders Lehmann

Sverker Von Unge

William Bert Geiss

Thomas M Stormann

Gunnel E Sundén

Paul L Andrews

Kevin Fitzpatrick

Paul L R Andrews

The present invention relates to the use of metabotropic glutamate receptor 5 antagonists for the inhibition of transient lower esophageal sphincter relaxations. A further aspect of the invention is directed to the use of metabotropic glutamate receptor 5 antagonists for the treatment of gastroesophageal reflux disease, as well as for the treatment of regurgitation.

Use of mGluR5 antagonists for the treatment of gerd

Novel compounds of formula I, with the exception of 

Use of GabaB receptor agonists

The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed.

Treatment of gastroesophageal reflux disease

The present invention relates to the use of GABAreceptor agonists for the treatment as well as the prevention of cough.

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Novel compounds of formula (I) wherein Rrepresents hydrogen; Rrepresents hydroxy, fluoro, or an oxo group; Rrepresents hydrogen; Rrepresents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy

Compounds useful in reflux disease

The present invention relates to the use of GABA receptor agonists for the inhibition of transient lower esophageal sphincter relaxations, and for the treatment of gastro-esophageal reflux disease.

Growing community of inventors

Vastra Frolunda, Sweden

Anders Lehmann