Medivir Ab

Medivir Aktiebolag

Anders Eneroth

Bjorn Klasson

Richard Bethell

Fredrik Oberg

Björn Klasson

Mark Albertella

John Öhd

Fredrik Öberg

Richard Bethel

The invention provides compounds of the formula: 

Dioxolane analogues of uridine for the treatment of cancer

Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine with the formula: where Y is C-Cstraight or branched chain alkyl, X is H, halo, C-Ccycloalkyl or C-Calkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis.

Sorafenib or regorafenib troxacitabine phosphoramidate prodrug combination therapy for liver cancer

Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine with the formula: where Y is C-Cstraight or branched chain alkyl, X is H, halo, C-Ccycloalkyl or C-Calkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis. 

Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

The invention provides compounds of the formula:  Ris OR, or NRR'; Ris H or F; Ris H, C-Calkyl, OH, C(&#x2550;O)R, O(C&#x2550;O)Ror O(C&#x2550;O)OR; Ris H or C-Calkyl; Ris C-Calkyl or C-Ccycloalkyl; Ris H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

Growing community of inventors

Huddinge, Sweden

Anders Eneroth