St. Jude Medical Ab

Pacesetter, Inc.

St Jude Medical, Atrial Fibrillation Division, Inc

Anders Björling

Paul A Levine

Kyungmoo Ryu

Stuart Rosenberg

Nils Holmström

Karin Järverud

Karin Ljungström

Hans G Strandberg

Sven Kalling

Eric Steven Fain

Timothy A Fayram

Kenth A Nilsson

Sven-Erik Hedberg

Göran Budgifvars

Kjell Noren

Allen J Keel

Kjell Norén

Maria Torpo

Rupinder Bharmi

Martin Obel

Ulf Lindegren

Anders Lindgren

Hans Abrahamson

Tomas Svensson

Johan Eckerdal

Malin Öhlander

Leif Sörnmo

Tom Eriksson

Michael Broome

Asa Uhrenius

Stefan Hjelm

Tomas Snitting

Malin Hollmark

Per Lagercrantz

Anna-Karin Johansson

Michael Broomé

Cecilia Emanuelsson

Magnus Aström

Lars Mandal

Sven Erik Hedberg

Urban Lönn

Johan Svahn

Cecilia Tuvstedt

In response to local or systemic inflammation in a patient, photobiomodulation therapy is applied to a cardiac location to reduce the risk and/or occurrence of cardiac arrhythmia. Once inflammation is identified, photobiomodulation therapy can be applied in any suitable fashion (e.g., via a catheter- or transesophageal probe-mounted photoemitter, via an externally-applied photoemitter, or via photoemitter incorporated into an implantable medical device). Photobiomodulation therapy can also be employed to good advantage in conjunction with non-photobiomodulation therapy (e.g., traditional cardiac rhythm management therapies).

Method of reducing the occurrence of arrhythmias via photobiomodulation and apparatus for same

In an implantable heart stimulating device and a method of the operation thereof, device has a control circuit that detects an evoked responses to delivered pacing pulses and to carry out an automatic capture routine. The control circuit is arranged to automatically temporarily disable the automatic capture routine on the basis of at least one of the following criteria:

Implantable heart stimulating device and method

In an implantable medical device such as an implantable cardiac defibrillator, and a method for classifying arrhythmia events, IEGM signals are analyzed to detect an arrhythmia event and a respiratory pattern of the patient is sensed. At least one respiratory parameter reflecting characteristics of the respiratory pattern of the patient is determined based on the sensed respiratory pattern and a respiratory measure corresponding to a change of a rate of change of the at least one respiratory parameter is calculated. The detected arrhythmia event is classified based on the respiratory measure and the IEGM signals, wherein arrhythmia events that satisfy at least a first criterion is classified as an arrhythmia event requiring therapy.

Implantable medical device and method for classifying arrhythmia events

An implantable medical device () is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart () of a subject () during at least a portion of cardiac cycle. A moment processor () calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier () in order to classify a detected arrhythmia of the heart (), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.

Implantable medical device and method comprising means for detecting and classifying an arrhythmia

In a method and an implantable medical device for assessing a degree of pulmonary edema of a patient, at least two specific body patients of the patent are detected and at least one impedance sensing session is initiated to sense trans-thoracic impedance signals from the patient when the patient is in one of the at least two specific positions. Impedance values are obtained from the impedance signals, and a relation between respective impedance values at the at least two positions is determined. This relation is then used as a metric of pulmonary edema to assess the degree of pulmonary edema, and is provided as an output.

Method and implantable medical device for assessing a degree of pulmonary edema of a patient

An analyte measuring system has an implantable medical device having a signal source arranged for generating a current signal and electrodes for applying the current signal to a surrounding tissue in a subject body. The device measures a resulting voltage signal with the electrodes and calculates an impedance signal therefrom. The system comprises a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectrum analysis of the determined impedance signal.

Implantable medical device

In an implantable heart stimulator and a method for operation thereof, stimulation pulses are delivered to a heart. The amplitude of the delivered stimulation pulses can be selectively set. For setting the amplitude, threshold searches are performed at selected time intervals. Each threshold search determines a threshold value required for achieving capture. The amplitudes of the respective stimulation pulses are set to a value that exceeds the determined threshold value by a safety margin. The safety margin is selected as a function of the selected time intervals.

Implantable heart stimulator and method for operation thereof

Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.

Implantable systemic blood pressure measurement systems and methods

In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.

Biventricular heart stimulator and method of controlling a biventricular heart stimulator

In a device and method in a dual chamber pacing system operating in an atrial synchronized mode, the cardiac stimulator is connectable to a lead arrangement arranged for sensing atrial electrical and mechanical activity. Upon detection of an atrial arrhythmia based on either of sensed atrial mechanical activity, atrial electrical activity, or a combination thereof, a mode switch from an atrial synchronized ventricle stimulating mode to a non-atrial synchronized mode is triggered.

Method, device, implantable stimulator and dual chamber cardiac therapy system

An implantable cardiac stimulation device has an atrial detector that detects atrial events of a patient's heart, and a memory in which sequences of IEGM signals are stored, having a predetermined length, and an analyzing unit that analyzes the sequences to determine if the stored sequences contain atrial events having a lower amplitude than the current sensitivity setting of the atrial detector. A control unit is connected to the atrial detector to adjust the sensitivity setting thereof to a threshold that is determined based on the aforementioned analysis of the IEGM signals.

Device for adjusting the sensitivity level of an implantable medical device

In an implantable biventricular heart stimulating device, and a biventricular heart stimulating method, wherein operation takes place normally with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit, and wherein a time VVis determined that is to be used instead of VV during a capture threshold search.

Implantable biventricular heart stimulating device and method for performing a capture threshold search

An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one DHF parameter for detecting a DHF state of the heart of a patient. The DHF includes circuitry for determining, as the DHF parameter, the time duration of a predetermined phase of diastole. A pacemaker has such an apparatus and a control unit that optimizes pacing therapy and pacemaker settings depending on the determined time duration. A corresponding method of detecting diastolic heart failure, DHF, includes determining at least one DHF parameter for detecting a DHF state of the heart of a patient. As the DHF parameter, the time duration of a predetermined phase of diastole is determined.

Apparatus for detecting diastolic heart failure

An implantable heart stimulating device for indicating congestive heart failure (CHF) has a processor, an activity sensor that generates an activity signal indicative of a patient's activity, and a blood temperature sensor that measures blood temperature inside the heart of the patient and generates a temperature signal indicative of the measured temperature. From the activity signal and the temperature signal, the processor identifies a characteristic dip in the temperature signal related to a predetermined increase in the activity signal. The processor determines a CHF indicator value indicating the degree of CHF based on the magnitude of the temperature sensor dip for at least two increased activity levels.

Heart stimulating device

In an ischemia detection method, and in an ischemia detector and a cardiac stimulator embodying an ischemia detector, a workload of a patient is measured, as is an ejection fraction (EF) associated with the heart of the patient is determined. A predetermined reference relation between EF and workload for the patient is stored, and an analysis unit detects a state of ischemia of the patient from deviation in the determined EF for various workloads from the stored reference relation.

Detection of ischemia

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Järfälla, Sweden

Anders Björling