Schering Aktiengesellschaft

Jenapharm Gmbh

Anatoli Kurischko

Gerd Schubert

Kurt Ponsold

Helmut Kasch

Gudrun Bertram

Walter Elger

Michael Oettel

Bernd Menzenbach

Heidemarie Rohrig

Lothar Sobeck

G Unther Kaufmann

Gunther Kaufmann

The invention relates to 11.beta.-aryl-gona-4,9-dienes of formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone synthesis inhibitors and are suitable for inducing labor or an abortion, and for treating endometriosis, dysmenorrhea, and endocrine hormone-dependent tumors.

11 Beta-aryl-gona-4, 9-dien-3-ones

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds. The compounds described show strong antigestagenic effects combined with reduced glucocorticoid activity.

11-benzaldoxime-estra-diene derivatives, methods for their production

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## wherein Z is --CO--CH.sub.3, --CO--O--C.sub.2 H.sub.5, --CO--NH-phenyl, --CO--NH--C.sub.2 H.sub.5, --CO--C.sub.2 H.sub.5, --CH.sub.3, or --CO-phenyl and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds. The compounds of the general formula I are produced by esterifying or etherizing a compound of the general formula II ##STR2## The compounds described show strong antigestagenic effects combined with reduced glucocorticoid activity.

11-benzaldoxime-17.beta.-methoxy-17.alpha.-methoxymethyl-estrasdiene

This invention relates to 11.beta.-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are suitable for inducing labor or an abortion.

11.beta.-aryl-gona-4,9-dien-3-ones

11.sym.-Aryl-16.alpha.,17.alpha.-cyclohexano-estra-4,9-dienes of formula ##STR1## wherein R.sup.1 is H or a methyl group;

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Jena, Germany

Anatoli Kurischko