The UAB Research Foundation (The University of Alabama at Birmingham)

Southern Research Institute

Anath Shalev

Mark J Suto

Corinne E Augelli-Szafran

Omar Moukha-Chafiq

Lance Thielen

Junqin Chen

Gu Jing

Guanlan Xu

In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted quinazoline sulfonamides as thioredoxin interacting protein (TXNIP) inhibitors

In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels.

The present invention provides compositions and methods for regulating insulin production.

Methods and compositions for modulating MIR-204 activity

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Mountain Brook, AL, United States of America

Anath Shalev