Transmedics, Inc.

Anas Abdelazim

Waleed H Hassanein

Tamer I Khayal

Robert Havener

Ihab Abdel Fattah

Scott W Newell

Richard Bringham

John Sullivan

Stanley Kyi

Robert Fishman

Mark Anderson

Michael Van Driel

Doug Harriott

Matthew De Remer

Paul Murray

Ron Taylor

Tom Bishop

Thomas H Bishop

Ronald Taylor

Paul Lezberg

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.

Organ care solution for ex-vivo machine perfusion of donor lungs

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North Andover, MA, United States of America

Anas Abdelazim