Flagship Pioneering Innovations Vi, LLC

Ananya Ray

Barrett Ethan Steinberg

Anne Helen Bothmer

Nathaniel Roquet

Randi Michelle Kotlar

Cecilia Giovanna Silvia Cotta-Ramusino

Robert Charles Altshuler

Carlos Sanchez

Robert James Citorik

William Edward Salomon

Kyusik Kim

Jacob Rosenblum Rubens

Zi Jun Wang

Sandeep Kumar

Aamir Mir

Gregory David McAllister

Zhan Wang

William Querbes

Luciano Henrique Apponi

Daniel Raymond Chee

Methods and compositions for modulating a target genome are disclosed. This disclosure relates to novel compositions, systems and methods for altering a genome at one or more locations in a host cell, tissue or subject, in vivo or in vitro. In particular, the invention features compositions, systems and methods for inserting, altering, or deleting sequences of interest in a host genome.

Methods and compositions for modulating a genome

The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

CFTR-modulating compositions and methods

The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.

Growing community of inventors

Melrose, MA, United States of America

Ananya Ray