Circuit Therapeutics, Inc.

Alector LLC

Ananya Mitra

Dan E Andersen

David F Moore

Alexander K Arrow

Joyce Huang

Greg Stahler

Arnon Rosenthal

Jeonghoon Sun

Wei-Hsien Ho

Tina Schwabe

Herve Rhinn

Ilaria Tassi

Angie Grace Yee

Philip Ling Kong

Muhammad Abbas Alhawagri

Hua Long

Santiago Viveros Salazar

Daniel P Bermingham

Francesca Cignarella

Klaus-Dieter Heger

Karpagam Srinivasan

The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Anti-MS4A4A antibodies and methods of use thereof

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

System and method for optogenetic therapy

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Menlo Park, CA, United States of America

Ananya Mitra