Leland Stanford Junior University

Ananth Srinivasan

Sanjiv Sam Gambhir

Michelle Louise James

Mohammad Namavari

Gayatri Gowrishankar

Israt Shamima Alam

Corrine Gaye Beinat

Embodiments of the present disclosure provide for labeled probes such as labeled maltoside probes and labeled maltotriose probes, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, and the like.

Probes and methods of imaging a bacterial infection

The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of theF isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2

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Stanford, CA, United States of America

Ananth Srinivasan