Xeltis Ag

Technische Universiteit Eindhoven

Xeltis B.v.

Anandkumar Nandakumar

Martijn Antonius Johannes Cox

Anton Willem Bosman

Franciscus Petrus Thomas Baaijens

Patricia Yvonne Wilhelmina Dankers

Tristan Mes

Tom Lavrijsen

Carolina Victoria Catharina Bouten

Henricus Marie Janssen

Serge Hendrikus Mathijs Söntjens

Christophe Pierre Edouard Naz

Oleg Svanidze

Fabio Zomer Volpato

Serge Hendrikus Mathijs SÖNTJENS

The disclosure lies in the field of regenerative medicine and relates to an implant having a matrix material, and a method for manufacturing an implant having matrix material. The disclosure further relates to a crimped implant.

Implant

Endoluminal and other as implantable prostheses are fabricated in electrospinning apparatus including a target and an applicator. A solution comprising a polymer and a solvent is directed to the target with a first electrical potential between the target and the applicator to produce a first set of fibers. The same or another solution is continued to be delivered through the applicator onto the target while applying a second electrical potential to produce a second set of fibers having a second solvent fraction, and the same or different solution may be delivered while applying a third potential difference to produce a laminated structure having at least three layers. By properly controlling the electrical potentials and solvent fractions, an adhesive layer can be formed to serve a glue or adhesive between the inner and outer layers, and a stent or other scaffold may be positioned between the inner and outer layers to form a covered stent or graft.

Methods for electrospin coating and laminating of endoluminal prostheses

Growing community of inventors

The Hague, Netherlands

Anandkumar Nandakumar