Dabur Research Foundation

Dabur Pharma Limited

Anand Vardhan

Sunder Ramadoss

Manu Jaggi

Rama Mukherjee

Anand C Burman

Anu T Singh

Vivek Kumar

Manoj Kumar Singh

Praveen Rajendran

Mohammad Jamshed Ahmed Siddiqui

Arvind Kumar Sharma

Shiv Kumar Agarwal

Hemant Kumar Jajoo

Nidhi Rani

Sanjay Kumar Srivastava

The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(&#x2550;CH)CHor CH(CH); Rtogether with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; Ror Rare hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or Rand Rare combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and Ris zero when Y is O, and Ris hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells. 

Betulinic acid derivatives

The invention provides novel paclitaxel derivatives obtained by effecting modifications at C , C and/or C positions of paclitaxel, said derivatives being useful in inhibiting the growth of cancer of lung, breast, ovary, cervix or leukemia, and pharmaceutical compositions comprising such derivatives.

Paclitaxel derivatives for the treatment of cancer

A novel process for isolation of 10-deacetyl baccatin-III (10-DAB) and also complete separation of paclitaxel present in the primary extract, on a commercial scale from plant extract of Taxus species by solvent crystallization without employing chromatographic separation.

Process for isolation of 10-deacetyl baccatin-III

Novel process for isolation of 14.beta.-hydroxy 10-deacetyl baccatin-III (14.beta.-OH-DAB) on a commercial scale from plant extract by solvent crystallization without employing chromatographic separation.

Process for the isolation of 14.beta.-hydroxy-10-deacetyl baccatin-III

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Uttar Pradesh, India

Anand Vardhan