Imperial Chemical Industries Limited

Zeneca Limited

Ici Americas, Inc.

Anand Swaroop Dutta

Christopher F Hayward

Diane A Trainor

Ronald Cotton

Richard A Wildonger

Gilbert J Stacey

Michael Brian Giles

John S Morley

James J Gormley

Ross L Stein

Roger Camble

Barrington John Furr

Nigel N Petter

Cell adhesion ihibiting compounds

Fibronectin adhesion inhibitors

Peptide inhibitors of fibronectine

The invention releates to a polypeptide of formula I

Polypeptide compounds

The invention relates to a polypeptide of formula I:

Bombesin antagonists with deletion of net-residue at the C-terminus

Proline derivatives

Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.

The disclosure relates to novel polypeptides which possess analgesic activity, to processes for their manufacture and to pharmaceutical compositions containing them. Typical of the peptides disclosed is: ##STR1##

Polypeptide

The disclosure relates to novel polypeptides which are analogues of luliberin and which possess luliberin antagonist activity, to processes for their manufacture and to compositions containing them. Typical of the polypeptides disclosed is ##STR1## in which A is D-Phe, D-Trp or a direct bond.

Luliberin analogs

The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is

Analgesic and sedative polypeptides

The disclosure relates to novel luliberin analogues which possess luliberin agonist activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is ##STR1## in which A is D-Phe, D-Tyr(Me) or D-Ser(Bu.sup.t).

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Macclesfield, United Kingdom

Anand Swaroop Dutta