University of Florida Research Foundation Inc

The University of New Mexico

Ecolab USA Inc.

Anand Parthasarathy

David G Whitten

Kirk S Schanze

Thomas S Corbitt

Eunkyung Ji

Dimitri Dascier

Eric H Hill

Linnea K Ista

Ying Wang

Xiaojin Harry Li

Motokatsu Ogawa

Scott Charles

Kirsten Nicole Cicotte

Harry Craig Pappas

Elizabeth LeBleu Dirk

Xuzhi Zhu

Yun Huang

Richard J Todd

Zhijun Zhou

Yanli Tang

Syed Rasheed

Subhadip Goswami

The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)

Water-in-oil lattices of water soluble or dispersible polymers and methods of using the same are presented. The lattices include phosphorus functional inversion agents that provide rapid and complete inversion of the lattices under conditions wherein the water source used to invert the latex is provided at high temperature, or includes a high level of total dissolved solids, or is both high temperature and high total dissolved solids.

Phosphorus functional inversion agents for water-in-oil latices and methods of use

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R-Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R-Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Conjugated polyelectrolytes and methods of using the same

Water-in-oil latices of water soluble or dispersible polymers and methods of using the same are presented. The latices include nonionic inversion agents that provide rapid and complete inversion of the latices under conditions wherein the water source used to invert the latex is provided at high temperature, or includes a high level of total dissolved solids, or is both high temperature and high total dissolved solids.

Nonionic inversion agents for water-in-oil latices and methods of use

The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for oligo phenylene ethynylenes (OPEs)

The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

Antimicrobial materials and methods

Water-in-oil latices of water soluble or dispersible polymers and methods of using the same are presented. The latices include carbonyl functional inversion agents that provide rapid and complete inversion of the latices under conditions wherein the water source used to invert the latex is provided at high temperature, or includes a high level of total dissolved solids, or is both high temperature and high total dissolved solids.

Carbonyl functional inversion agents for water-in-oil latices and methods of use

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R&#x2014;Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R&#x2014;Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties againstboth under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

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Naperville, IL, United States of America

Anand Parthasarathy