Technicon Instruments Corporation

Miles Inc.

University of California

Bayer Corporation

Anand Kumar

Bronislaw P Czech

Eddy Chapoteau

Koon-Wah Leong

Carl R Gebauer

Donald J Cram

Roger C Helgeson

Paul G Gherson

Jonathan Craine

Salvatore J Pace

Milt Pelavin

The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions.

Metal ion determination by sandwich aggregation assay

An analysis method and apparatus comprises feeding a stream of fluid capsules in a fluid conduit for flow therethrough by forming a film of isolating liquid on an inner surface of the conduit and randomly accessing each of a plurality of liquids selected from a sample liquid, reagents and a magnetic particle suspension to form a plurality of isolated segments from the plurality of liquids in each capsule in the conduit. The fluid capsules flow in at least one longitudinal direction of the conduit and the suspended magnetic particles are selectively magnetically retained from one segment in one capsule at a given location for placement of the magnetic particles in another segment in the one capsule during the flow of the one capsule through the conduit. The fluid capsules are then measured in the conduit.

Capsule chemistry sample liquid analysis system and method

A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2,

Colorimetric method and reagent for the assay of lithium in a test sample

The present invention resides in the discovery of a new class of compounds defined herein as 'chromogenic hemispherands' useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;

Chromogenic hemispherands and their preparation

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;

Method for determining the concentration of cations in a sample

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;

Reagents for determining cations

Reagent for determining cations

The present invention resides in the discovery of a new class of compounds defined herein as 'chromogenic cryptahemispherands' useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;

Chromogenic cryptahemispherands and their preparation

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising

Chromogenic cryptand reagents and methods for determining cation

The present invention resides in the discovery of a new class of compounds defined herein as 'chromogenic hemispherands' useful for the measurement of ions, in particular, ions in aqueous solution, methods of using the chromogenic hemispherands and test devices containing the chromogenic hemispherands. The chromogenic hemispherands of the invention have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;

Method of detecting electrolytes in an aqueous test sample using

The present invention resides in the discovery of a class of compounds defined herein as 'chromogenic cryptahemispherands' useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;

Method for detecting cations in a test sample utilizing chromogenic

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;

Compounds, reagents and procedures for determining cations

Immunoassays featuring voltammetric measurements wherein at least one of the immunoreactants is labelled with an electroactive substance. Measurement is effectedon a pulsed-basis to maximize the signal change due to the electron transfer capabilities of the labelled immunoreactants.

Electrode for voltammetric immunoassay

A method and reagents are disclosed for minimizing interference from halide ions in ion-selective electrode analysis. A reagent consisting of a mixture of a metal and a chelating agent is introduced to the fluid sample being analyzed. This reagent forms soluble complexes with halide ions in the fluid sample, thus minimizing their effects.

Growing community of inventors

Southfields, NY, United States of America

Anand Kumar