Other

Université De Nantes

Institute for Molecular Medicine, Inc.

Uni Vax

Oncomune, LLC

Anahit Ghochikyan

Michael Agadjanyan

Vehary Sakanyan

Francoise-Michèle Lecocq

Marina Snapyan

Michael G Agadjanyan

The disclosure provides methods of treating tauopathies (e.g. Alzheimer's disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia with Parkinsonism linked to chromosome 17, Pick's Disease, Progressive Supranuclear Palsy, Dementia Pugilistica, Down's Syndrome and others) by administering humanized antibodies. The disclosure also provides the anti-tau humanized antibodies that bind the N-terminal region of tau and also bind to pathological tau aggregates, conformational epitopes and peptides mimicking these epitopes (mimotopes).

Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies

Disclosed are compositions, comprising one or more immunogens, wherein each immunogen comprises at least two regions, wherein one region comprises at least one amyloid-&#x3b2; (A&#x3b2;) B cell epitope or at least one Tau B cell epitope or at least one &#x3b1;-synuclein B cell epitope or combinations thereof, and a second region comprises at least one foreign T helper cell (Th) epitope, and usually multiple foreign Th epitopes. Methods of making and using the compositions are also disclosed.

Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein

Polynucleotides encoding a nonfunctional mutant form of the Brother of Regulator of Imprinted Sites (BORIS) molecule, nonfunctional mutated BORIS protein, polypeptide or peptide and modified protein forms of BORIS are described. These molecules are used as a therapeutic vaccine against cancer.

Cancer vaccine based on brother of regulator of imprinted sites molecule (BORIS)

Cancer vaccine based on brother of regulator of imprinted sites molecule

The present invention relates to methods for RNA and/or protein synthesis using in vitro or in vivo expression systems. More specifically, the present invention provides a method for RNA and/or protein synthesis characterized in that the concentration of alpha subunit of RNA polymerase, but not of other subunits, is increased in the cellular or cell-free system, comparing to its natural concentration existing in the cellular or cell-free system.

Methods of RNA and protein synthesis

Growing community of inventors

Huntington Beach, CA, United States of America

Anahit Ghochikyan