Mesoscale Technologies, Llc.

Anahit Aghvanyan

Eli N Glezer

John H Kenten

Martin Stengelin

George B Sigal

David Routenberg

Sudeep Kumar

Galina Nikolenko

Srikant Vaithilingam

The present invention is directed to methods for improving assay specificity and performance in binding assays.

Assay methods

The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Lung cancer biomarkers

The present invention is directed to kits for improving assay specificity and performance in binding assays.

Assay kits

The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

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Gaithersburg, MD, United States of America

Anahit Aghvanyan