Gruppo Lepetit

Biosearch Italia S.p.a.

Anacleto Gianantonio

Gianbattista Panzone

Ernesto Oppici

Giambattista Panzone

Giancarlo Lancini

Ermenegildo Restelli

Alessandra Maria Marazzi

Giorgio Montorsi

Francesco Assi

Renato Pellizzato

Improved chemical process for preparing the compounds of formula (I), wherein: R,represents (C,-C,)alkyl; M represents hydrogen, &agr;-D-mannopyranosyl or 6-O-acetyl-&agr;-D-mannopyranosyl and Y represents an amino group of formula &mdash;NR,-alk,-(NR,-alk,),-(NR,-alk,),-W. One aspect of the invention refers to the preparation of the intermediate compound of formula (III) (which corresponds to the above compound of formula (I)

Chemical process for preparing amide derivatives of antibiotic A 40926

The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acid hydrolysis in the presence of an organic aprotic solvent, and a purification thereof.

Chemical process for preparing antibiotic L 17932 (deglucoteicoplanin)

The present invention relates to a new one-pot process for preparing 2'-(diethylamino)rifamycin P and its 25-desacetyl derivative which consists in cyclizing 3-bromorifamycin S or its 25-desacetyl derivative, dissolved in dimethylformamide, with 1,1-diethylthiourea and reducing, without isolation, the obtained 1,2-quinonimine intermediate with a mild reducing agent.

Process for preparing 2'-(diethylamino)rifamycin P (P/DEA)

This invention concerns the recovery of glycopeptidic antibiotics from aqueous solutions resulting from fermentation broths or process streams. Examples of glycopeptidicantibiotics to which the process of this invention may be applied are the following: vancomycin, actaplanin, ristocetin, avoparcin, actinoidin, LL-AM-374, A 477, OA 7653, A 35512 B, A 515668, AAD 216, A 41030, A 47934, A-40926 (European Pat. Appln. No. 85112406.5), the individual factors, derivatives and pseudo-aglycones and aglycones thereof, teicoplanin and teicoplanin-like compounds.

Process for recovery of glycopeptidic antibiotics

The object of this invention is to provide a method for selectively increasing the ratio of the single T-A2 major components in the T-A2 complex. More particularly, the object of this invention is a process for obtaining teicoplanin A.sub.2 selectively enriched in any of its major components, T-A2-1, T-A2-2, T-A2-3, T-A2-4 and T-A2-5 which consists in adding to the culture medium of Actinoplanes teichomyceticus nov. sp. ATCC 31121 or a mutant thereof which produces T-A2 complex through the same metabolic pathway, a selectively effective amount of an appropriate precursor.

Method for selectively increasing the ratio of single major components

A process for preparing 6-APA and 7-ACA and derivatives therefore is disclosed wherein a penicillin or cephalosporin substrate is reacted with a molar excess of an oxalyl halide of the formula halCOCOhal whereby the COOM group of the substrate, wherein M represents hydrogen, metal or ammonium cations, is transformed into the group COOCOCOhal.

Process for preparing 6-aminopenicillanic acid, 7-aminocephalosporanic

High yields of phthalaldehydic acid from .alpha.,.alpha.,.alpha.,.alpha.',.alpha.'-pentachloro-o-xylene can be obtained in an excellent degree of purity if a mixture of said pentachloroxylene and phthalaldehydic acid in water is heated to a temperature between about 80.degree. and about 180.degree. C., and preferably at the boiling temperature of the reaction mixture. The mutual ratio of the reactants is not critical, and may vary within wide ranges, although it is usually preferred to have such a ratio between the said pentachloroxylene and phthalaldehydic acid that for each part by weight of the former at least 0.1 part by weight of the latter is present. Practically, there is no upper limit to the amount of phthalaldehydic acid which may be present, even to a large molecular excess.

Preparation of phthalaldehydic acid from

Cephalosporin C is recovered from its fermentation broth by in situ formation of N-(p-nitrobenzoyl)cephalosporin C which is extracted therefrom and converted to 7-amino-cephalosporanic acid.

Growing community of inventors

Milan, Italy

Anacleto Gianantonio